Acronyms dictionary DDF What does DDF mean? DDF is an acronym, used on dating websites or personal ads, that stands for drug disease free or drug and disease free. Examples of DDF You must be open minded, clean, Ddf, no drinking or partier, help keep the place clean and organized. Craigslist Post, March, 2018 I asked an online ''friend'' of mine his HIV status prior to us meeting up. He replied '' I am DDF and only PLAY SAFE''. RealJock Post, November, 2010 Yes, I'm sick with the cold and I'm still looking to hookup on Grindr and start my New Years with a bang. It's not my fault they only ask if I'm ddf. @LOONAirrr, December, 2017 SEE MORE EXAMPLES Just Added Black Music Appreciation Month, Older Americans Month, Mental Health Awareness Month, Jewish American Heritage Month, Asian American and Pacific Islander Heritage Month Note This is not meant to be a formal definition of DDF like most terms we define on Dictionary.com, but is rather an informal word summary that hopefully touches upon the key aspects of the meaning and usage of DDF that will help our users expand their word mastery.