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Down's syndrome

British  

noun

    1. Former name: mongolism.  Technical name: trisomy 21offensive pathol a condition caused by the presence of an extra copy of chromosome 21 resulting in learning difficulties and physical differences, such as shorter stature

    2. ( as modifier )

      a Down's syndrome baby

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Down's syndrome Cultural  
  1. A congenital condition, caused by an abnormality in the chromosomes, marked by moderate to severe mental retardation and changes in certain physical features.


Usage

Although the condition was once generally known as mongolism , this term has been considered offensive since the early 1960s. The terms Down's syndrome or ( US ) Down syndrom are now preferred.

Etymology

Origin of Down's syndrome

C19: after John Langdon-Down (1828–96), English physician

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

But he says the whole point of it was to share how having someone in his life with Down's syndrome is "one of the best things in the world".

From BBC Jul. 26, 2026

In the well-maintained gardens, young adults – some with Down's syndrome, others with cerebral palsy, and autism - carefully tend their crops.

From BBC Apr. 5, 2026

It comes after the BBC flagged dozens of profiles showing AI-generated images of women with disabilities, including Down's syndrome or vitiligo.

From BBC Feb. 26, 2026

Ailith Harley-Roberts, whose daughter Thalia has Down's syndrome, says the government plans have prompted concern among parents she knows through her charity Sunshine and Smiles, which supports families like hers.

From BBC Feb. 24, 2026

Joel has Down's syndrome, among other health conditions but paediatrician Dr Niamh Lynch said flu could be serious for any child.

From BBC Jan. 13, 2026

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