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Down's syndrome

British  

noun

    1. Former name: mongolism. Technical name: trisomy 21. offensive pathol a condition caused by the presence of an extra copy of chromosome 21 resulting in learning difficulties and physical differences, such as shorter stature

    2. ( as modifier )

      a Down's syndrome baby

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Down's syndrome Cultural  
  1. A congenital condition, caused by an abnormality in the chromosomes, marked by moderate to severe mental retardation and changes in certain physical features.


Usage

Although the condition was once generally known as mongolism , this term has been considered offensive since the early 1960s. The terms Down's syndrome or ( US ) Down syndrom are now preferred.

Etymology

Origin of Down's syndrome

C19: after John Langdon-Down (1828–96), English physician


Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

But he says the whole point of it was to share how having someone in his life with Down's syndrome is "one of the best things in the world".

From BBC ● Jul. 26, 2026

It comes after the BBC flagged dozens of profiles showing AI-generated images of women with disabilities, including Down's syndrome or vitiligo.

From BBC ● Feb. 26, 2026

Carers, parents and other young people with conditions like cerebral palsy and Down's syndrome are also welcome.

From BBC ● Feb. 6, 2026

Dot Gallagher's son Michael, 38, is in a relationship with Alison Williams, 42, and they both have Down's syndrome.

From BBC ● Dec. 28, 2025

But Goldstein - who is the first star with Down's syndrome to take part in a regular series of the dance show - also gave an insight into what she is most looking forward to.

From BBC ● Sep. 26, 2025

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