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Down's syndrome

British  

noun

    1. Former name: mongolism.  Technical name: trisomy 21offensive pathol a condition caused by the presence of an extra copy of chromosome 21 resulting in learning difficulties and physical differences, such as shorter stature

    2. ( as modifier )

      a Down's syndrome baby

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Down's syndrome Cultural  
  1. A congenital condition, caused by an abnormality in the chromosomes, marked by moderate to severe mental retardation and changes in certain physical features.


Usage

Although the condition was once generally known as mongolism , this term has been considered offensive since the early 1960s. The terms Down's syndrome or ( US ) Down syndrom are now preferred.

Etymology

Origin of Down's syndrome

C19: after John Langdon-Down (1828–96), English physician

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Ailith Harley-Roberts, whose daughter Thalia has Down's syndrome, says the government plans have prompted concern among parents she knows through her charity Sunshine and Smiles, which supports families like hers.

From BBC • Feb. 24, 2026

Carers, parents and other young people with conditions like cerebral palsy and Down's syndrome are also welcome.

From BBC • Feb. 6, 2026

Ellie has had hundreds of messages over the last few months from families who have relatives with Down's syndrome.

From BBC • Dec. 31, 2025

"On an Aitch level, I feel like I have got this calling to raise awareness for Down's syndrome and I feel that's the perfect place."

From BBC • Nov. 11, 2025

Ms Pickard, 41, who also works for Mencap Cymru, said having Down's syndrome was like a hurdles race.

From BBC • Sep. 9, 2025

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