nucleosome

American  

[noo-klee-uh-sohm, nyoo-] / ˈnu kli əˌsoʊm, ˈnju- /

noun

Cell Biology.

1. any of the repeating subunits of chromatin occurring at intervals along a strand of DNA, consisting of DNA coiled around histone.

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nucleosome British  

/ ˈnjuːklɪəˌsəʊm /

noun

1. a repeating structural unit of chromatin that contains DNA and histones

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nucleosome Scientific  

/ no̅o̅′klē-ə-sōm′ /

1. Any of the repeating subunits of chromatin in eukaryotic cells, consisting of a DNA chain coiled around a core of histones.

2. See Note at histone

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Etymology

Origin of nucleosome

First recorded in 1960–65; nucleo- + -some ³

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Example Sentences

See Examples For:

nucleosome

The nucleosome forms a fundamental repeating unit of chromatin.

From Science Daily ● Mar. 7, 2024

Each nucleosome consists of approximately 147 base pairs of DNA wrapped around a histone octamer which is composed of two H2A-H2B dimers and one H3-H4 tetramer.

From Science Daily ● Mar. 7, 2024

Because genomic DNA is folded around histone proteins to create nucleosome complexes, nucleosomes physically regulate the access of proteins, such as transcription factors and enzymes, to the underlying DNA.

From Textbooks ● Jun. 9, 2022

The observation of chromatin modifier genes being frequently mutated in ccRCC strongly supports the model of nucleosome dynamics, providing a key function in renal tumorigenesis.

From Nature ● Jul. 3, 2013

A nucleosome is a single, wrapped DNA-histone complex.

From Textbooks ● Jun. 19, 2013

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