The tripwire for an unfolding plot to take control of the flight would be the transponder, operated by a switch beside the pilots.
Some more recent examples: Intel was founded in 1968 and operated in a highly competitive, capital intensive industry.
During two years in Iranian custody, Abdolhamid provided crucial details of how Jundullah operated.
According to Saudi media accounts, he operated in Syria for several years before moving to Pakistan.
Remember the Stasi, the secret police who operated in East Germany when it was a communist state?
All cases of phimosis should be operated upon in infancy, by complete or partial circumcision.
The Union Store was finished, stocked, and operated, but its life was brief.
He, also, was fishing, and I was curious to learn just how he operated.
The concrete was mixed by a machine of the Ransome type, operated by a 12-HP.
It achieved its greatest fame as the railroad which first operated a locomotive of American manufacture.
c.1600, "to be in effect," back-formation from operation, or else from Latin operatus, past participle of operari "to work, labor, toil, take pains" (in Late Latin "to have effect, be active, cause"). Surgical sense is first attested 1799. Meaning "to work machinery" is from 1864 in American English. Related: Operated; operating. Operating system in the computer sense is from 1961.
operate op·er·ate (ŏp'ə-rāt')
v. op·er·at·ed, op·er·at·ing, op·er·ates
To perform surgery.