base editing

American  

[bays ed-it-ing] / ˈbeɪs ˌɛd ɪt ɪŋ /

noun

1. Genetics. a precise gene editing technique in which a single base or nucleotide (represented by a letter) is replaced by another in the sequence of a piece of DNA.

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Other Word Forms

• base editor
  noun
• base-edited
  adjective

Example Sentences

See Examples For:

base editing

The technology Egli’s group used, called base editing, allows them to target individual DNA letters in sequences more precisely with fewer adverse effects.

From The Wall Street Journal ● Jun. 5, 2026

That said, sometimes off-target or incomplete editing happens with base editing, resulting in so-called “mosaics,” which are genetic mixtures of edited and unedited cells.

From The Wall Street Journal ● Jun. 5, 2026

With base editing, developed in 2016, researchers can engineer point mutations, but not all possible point mutations.

From Science Daily ● Mar. 12, 2024

So doctors at Great Ormond Street Hospital used "base editing" to perform a feat of biological engineering to build her a new living drug.

From BBC ● Dec. 10, 2022

Seidman says the team is encouraged by a recent success at using DNA base editing to repair heart cells and other kinds in mice with progeria, a disease that causes children to age rapidly.

From Science Magazine ● Jul. 28, 2022