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base editor

  • a word derived from base editing.
    base editing
    noun
    a precise gene editing technique in which a single base or nucleotide (represented by a letter) is replaced by another in the sequence of a piece of DNA.

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The feat relied on a blood infusion of a so-called base editor, designed to disable a liver protein, PCSK9, that regulates cholesterol.

From Science Magazine ● Nov. 11, 2023

Verve hopes its base editor could eventually be a one-time solution for tens of millions of middle-aged people who are struggling to control their cholesterol with daily drugs.

From Science Magazine ● Nov. 11, 2023

He says the PCSK9 base editor could one day be used to treat people who don’t have FH but have early heart disease.

From Science Magazine ● Nov. 11, 2023

However, two patients who already had severely blocked arteries had heart problems after the base editor infusion.

From Science Magazine ● Nov. 11, 2023

"Upon introduction of this small molecule, the two separate inactive fragments of the adenine base editor are glued together and rendered active," Zeng said.

From Science Daily ● Sep. 21, 2023

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