base editing

American  

[bays ed-it-ing] / ˈbeɪs ˌɛd ɪt ɪŋ /

noun

1. Genetics. a precise gene editing technique in which a single base or nucleotide (represented by a letter) is replaced by another in the sequence of a piece of DNA.

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Other Word Forms

• base editor
  noun
• base-edited
  adjective

Example Sentences

See Examples For:

base editing

That said, sometimes off-target or incomplete editing happens with base editing, resulting in so-called “mosaics,” which are genetic mixtures of edited and unedited cells.

From The Wall Street Journal ● Jun. 5, 2026

A DNA-editing technique, base editing, was used on early-stage embryos to fix disease-causing mutations.

From The Wall Street Journal ● Jun. 5, 2026

With base editing, developed in 2016, researchers can engineer point mutations, but not all possible point mutations.

From Science Daily ● Mar. 12, 2024

The approach is more precise, and possibly safer, than disrupting a gene with CRISPR, the gene editing tool from which base editing is derived.

From Science Magazine ● Nov. 11, 2023

So there are already trials of base editing under way in sickle-cell disease, as well as high cholesterol that runs in families and the blood disorder beta-thalassemia.

From BBC ● Dec. 10, 2022