protein
Americannoun
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Biochemistry. any of numerous, highly varied organic molecules constituting a large portion of the mass of every life form and necessary in the diet of all animals and other nonphotosynthesizing organisms, composed of 20 or more amino acids linked in a genetically controlled linear sequence into one or more long polypeptide chains, the final shape and other properties of each protein being determined by the side chains of the amino acids and their chemical attachments: proteins include such specialized forms as collagen for supportive tissue, hemoglobin for transport, antibodies for immune defense, and enzymes for metabolism.
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the plant or animal tissue rich in such molecules, considered as a food source supplying essential amino acids to the body.
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(formerly) a substance thought to be the essential nitrogenous component of all organic bodies.
adjective
noun
Closer Look
Proteins are the true workhorses of the body, carrying out most of the chemical processes and making up the majority of cellular structures. Proteins are made up of long chains of amino acids, but they don't resemble linear pieces of spaghetti. The atoms in these long chains have their own attractive and repulsive properties. Some of the amino acids can form bonds with other molecules in the chain, kinking and twisting and folding into complicated, three-dimensional shapes, such as helixes or densely furrowed globular structures. These folded shapes are immensely important because they define the protein's function in the cell. Some protein shapes fit perfectly in cell receptors, turning chemical processes on and off, like a key in a lock, whereas others work to transport molecules throughout the body (hemoglobin's shape is ideal for carrying oxygen). When proteins fail to take on their preordained shapes, there can be serious consequences: misfolded proteins have been implicated in diseases such as Alzheimer's, mad cow, and Parkinson's, among others. Exactly how proteins are able to fold into their required shapes is poorly understood and remains a fundamental question in biochemistry.
Other Word Forms
Etymology
Origin of protein
First recorded in 1835–45; from German Protein, from Greek prōte(îos) “primary” + German -in -in 2; replacing proteine, from French; cf. proto- ( def. )
Explanation
Protein makes up your nails, your hair, and the egg on your plate. This nitrogenous substance we call protein consists of chains of amino acids and is necessary for life functions. The linguistic origins of protein — from the Greek proteios, meaning “first place” or “primary” — are fitting for a substance that is one of life’s chief components. Although protein is a word often heard in labs and biology classes, it has everyday context too, particularly in the kitchen. Protein-rich foods like eggs, cheese, meats, peanuts or beans are an essential part of good nutrition.
Vocabulary lists containing protein
Cell Biology - Middle School
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Genetics - Inheritance and Variation of Traits
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Genetics - Middle School
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Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
The El Segundo maker of plant-based proteins that look and taste like meat changed its website and social channels last week to reflect its new full name: Beyond the Plant Protein Co.
From Los Angeles Times • Mar. 10, 2026
Professor Payne is also set to lead the newly announced Australian Research Council Centre of Excellence for Advanced Peptide and Protein Engineering.
From Science Daily • Feb. 6, 2026
The firm is also pivoting towards health-focused products, with the launch of Doritos Protein later this year.
From BBC • Feb. 3, 2026
Witness the cereal aisle, home now to Cheerios Protein, Nature Valley Protein Granola and many more protein-infused brands.
From The Wall Street Journal • Jan. 14, 2026
But all I can talk her into is taking the Pure Protein sports bar I always carry in my bag in case my sandwich lets me down.
From "Nickel and Dimed: On (Not) Getting By in America" by Barbara Ehrenreich
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Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.