Paget's disease

American  

noun

1. Pathology. a chronic disease characterized by episodic accelerated bone resorption and growth of abnormal replacement bone, causing bone pain, deformation, fractures, and osteosarcoma; osteitis deformans.

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Paget's disease British  

/ ˈpædʒɪts /

noun

1. Also called: osteitis deformans.  a chronic disease of the bones characterized by inflammation and deformation

2. Also called: Paget's cancer.  cancer of the nipple and surrounding tissue

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Paget's disease Scientific  

/ păj′ĭts /

1. A disease, occurring chiefly in the elderly, in which the bones become enlarged and weakened, often resulting in fracture or deformity.

2. A breast cancer manifested by inflammatory changes of the nipple and surrounding skin.

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Etymology

Origin of Paget's disease

1875–80; named after Sir James Paget, who described it

Example Sentences

The ideal approach would include a multidisciplinary team of physicians, biologists, dietitians, psychologists, kinesiologists, etc., who, with the help of artificial intelligence, focus on reducing a patient’s biological age and with it age-related disease.

From The Wall Street Journal • Jun. 26, 2026

But each discovery gives scientists another possible route for targeting the biological processes that drive age-related disease.

From Science Daily • May 10, 2026

"Is this ageing or a new way to detect early age-related disease biomarkers? The authors favour the former, I don't think the latter is ruled out," he said.

From BBC • Dec. 6, 2023

Sustained infection control can use up naive T cell supplies and result in more exhausted T cells that circulate throughout the body and cause chronic inflammation, an important contributor to age-related disease.

From Washington Post • Jul. 18, 2022

Sayed envisions a future in which anyone can undergo inflammatory-biomarker profiling on a regular basis to keep tabs on their risk of developing age-related disease.

From Scientific American • Jul. 14, 2021