allosteric

American  

[al-uh-ster-ik, -steer-] / ˌæl əˈstɛr ɪk, -ˈstɪər- /

adjective

Biochemistry.

1. pertaining to regulation of the rate of an enzymatic process.

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allosteric British  

/ ˌæləʊˈstɪərɪk /

adjective

1. biochem of, relating to, or designating a function of an enzyme in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule

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Other Word Forms

• allosterically
  adverb

Etymology

Origin of allosteric

First recorded in 1960–65; allo- + steric

Example Sentences

The allosteric binding region is located between TAS2R14 and its coupled G protein is called G-protein alpha.

From Science Daily • Apr. 10, 2024

"It provided new insights into the allosteric network linking the ligand binding pocket to the G protein binding site that governs efficacy and potency."

From Science Daily • Dec. 21, 2023

Drugs that target allosteric sites are generally safer and more effective compared to drugs targeting active sites.

From Science Daily • Dec. 18, 2023

When an allosteric inhibitor binds to a region on an enzyme, all active sites on the protein subunits are changed slightly such that they bind their substrates with less efficiency.

From Textbooks • Apr. 25, 2013

In contrast, in allosteric activation, the activator molecule modifies the shape of the active site to allow a better fit of the substrate.

From Textbooks • Apr. 25, 2013