allosteric

American  

[al-uh-ster-ik, -steer-] / ˌæl əˈstɛr ɪk, -ˈstɪər- /

adjective

Biochemistry.

1. pertaining to regulation of the rate of an enzymatic process.

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allosteric British  

/ ˌæləʊˈstɪərɪk /

adjective

1. biochem of, relating to, or designating a function of an enzyme in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule

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Other Word Forms

• allosterically adverb

Etymology

Origin of allosteric

First recorded in 1960–65; allo- + steric

Example Sentences

However, in obese mice, allosteric regulation increased during feeding and decreased when fasting.

From Science Daily • Feb. 26, 2024

Researchers at the Centre for Genomic Regulation in Barcelona, Spain, and the Wellcome Sanger Institute near Cambridge, UK, have comprehensively identified the allosteric control sites found in the protein KRAS.

From Science Daily • Dec. 18, 2023

The drugs work by attaching to a pocket adjacent to the active site, inducing an allosteric conformational change in the protein that prevents it from being activated.

From Science Daily • Dec. 18, 2023

Additionally, ATP is an allosteric regulator of some of the enzymes involved in the catabolic breakdown of sugar, the process that creates ATP.

From Textbooks • Apr. 25, 2013

In contrast, in allosteric activation, the activator molecule modifies the shape of the active site to allow a better fit of the substrate.

From Textbooks • Apr. 25, 2013