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Showing results for amitriptyline. Search instead for amitriptylines.

amitriptyline

American  
[am-i-trip-tuh-leen, -lahyn, -lin] / ˌæm ɪˈtrɪp təˌlin, -ˌlaɪn, -lɪn /

noun

Pharmacology.
  1. a white crystalline powder, C 20 H 23 N, used to treat depression and enuresis.


amitriptyline British  
/ ˌæmɪˈtrɪptɪˌliːn, -lɪn /

noun

  1. a tricyclic antidepressant drug. Formula: C 20 H 23 N

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of amitriptyline

Perhaps ami(no)- + trypt(ophan) + (meth)yl + -ine 2

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Dr Toby Pillinger says: Sarah should have an antidepressant that avoids weight gain, such as agomelatine, sertraline or venlafaxine rather than amitriptyline or mirtazapine which are more likely to increase weight.

From BBC • Oct. 21, 2025

The results, published today in The Lancet, showed that patients taking amitriptyline were almost twice as likely to report an overall improvement in symptoms as those taking a placebo.

From Science Daily • Oct. 16, 2023

The first three “might be considered first choice” by doctors, they write, although the two most effective drugs – amitriptyline and venlafaxine – might still be first choice for severe depression.

From The Guardian • Feb. 21, 2018

Others have used low doses of tricyclic antidepressants, such as amitriptyline to treat chronic pain.

From US News • May 24, 2016

Because amitriptyline interferes with sweating, your body cannot dissipate extra heat as it normally would.

From Seattle Times • Aug. 1, 2012

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