asparaginase

American  

[uh-spar-uh-juh-neys, -neyz] / əˈspær ə dʒəˌneɪs, -ˌneɪz /

noun

Biochemistry, Pharmacology.

1. an enzyme that catalyzes the conversion of asparagine to aspartic acid and ammonia, used in the treatment of acute lymphocytic leukemia.

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Etymology

Origin of asparaginase

First recorded in 1960–65; asparagine + -ase

Example Sentences

"One is an earlier stage that is more resistant to asparaginase and another later stage that is more sensitive to it."

From Science Daily • Apr. 8, 2024

"Ideally, we aim for venetoclax to potentiate the anti-leukemia properties of asparaginase while keeping its toxicity levels in check. These concepts warrant further investigation in future clinical trials."

From Science Daily • Apr. 8, 2024

"Administering asparaginase alongside venetoclax may lower the risk of ALL relapse, the major reason for treatment failure," said co-author Ching-Hon Pui, MD, St. Jude Department of Oncology Fahad Nassar Al-Rashid Endowed Chair of Leukemia Research.

From Science Daily • Apr. 8, 2024

From this only 1/30 of an ounce of asparaginase can be extracted.

From Time Magazine Archive

They are produced by the colon bacteria from which asparaginase is extracted.

From Time Magazine Archive