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asparaginase

American

[uh-spar-uh-juh-neys, -neyz] / əˈspær ə dʒəˌneɪs, -ˌneɪz /

noun

Biochemistry, Pharmacology.

an enzyme that catalyzes the conversion of asparagine to aspartic acid and ammonia, used in the treatment of acute lymphocytic leukemia.

Etymology

Origin of asparaginase

First recorded in 1960–65; asparagine + -ase

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

"Ideally, we aim for venetoclax to potentiate the anti-leukemia properties of asparaginase while keeping its toxicity levels in check. These concepts warrant further investigation in future clinical trials."

From Science Daily • Apr. 8, 2024

"When you add asparaginase, you hit mTOR signaling," Yang said.

From Science Daily • Apr. 8, 2024

The largest hurdle was understanding how venetoclax works with asparaginase to stop B-cell leukemia.

From Science Daily • Apr. 8, 2024

They are produced by the colon bacteria from which asparaginase is extracted.

From Time Magazine Archive

If they lack this, they are dependent on borrowing asparagine from other cells, and asparaginase knocks out the floating supply, leaving none to be borrowed.

From Time Magazine Archive

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023