base editing

American  

[bays ed-it-ing] / ˈbeɪs ˌɛd ɪt ɪŋ /

noun

1. Genetics. a precise gene editing technique in which a single base or nucleotide (represented by a letter) is replaced by another in the sequence of a piece of DNA.

---

Other Word Forms

• base editor
  noun
• base-edited
  adjective

Example Sentences

See Examples For:

base editing

That said, sometimes off-target or incomplete editing happens with base editing, resulting in so-called “mosaics,” which are genetic mixtures of edited and unedited cells.

From The Wall Street Journal ● Jun. 5, 2026

The technology Egli’s group used, called base editing, allows them to target individual DNA letters in sequences more precisely with fewer adverse effects.

From The Wall Street Journal ● Jun. 5, 2026

Li then used base editing to create targeted amino acid changes in cancer cells.

From Science Daily ● Oct. 5, 2023

Newer methods such as base editing and prime editing that avoid double-break strands may be safer.

From Science Magazine ● Mar. 12, 2023

The team at Great Ormond Street used a technology called base editing, which was invented only six years ago.

From BBC ● Dec. 10, 2022