Benadryl

American  

[ben-uh-dril] / ˈbɛn ə drɪl /

Pharmacology, Trademark.

1. a brand of diphenhydramine.

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Benadryl British  

/ ˈbɛnədrɪl /

noun

1. an antihistamine drug used in sleeping tablets; diphenhydramine. Formula: C 17 H 21 NO

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Example Sentences

I was up almost every hour the first night and a few times the second, even with ear plugs from one of those Delta Air Lines in-flight amenity kits and Benadryl.

From The Wall Street Journal • Nov. 27, 2025

One night, a nurse gave him the painkiller Norco, the antipsychotic Haldol, the sedative Ativan and the antihistamine Benadryl, according to the report from the Department of Public Health.

From Los Angeles Times • Mar. 20, 2025

At issue is phenylephrine, an almost-century-old ingredient in versions of Benadryl, Mucinex, Tylenol and other over-the-counter pills, syrups and liquids to clear up congested noses.

From Slate • Sep. 13, 2023

If the F.D.A. ordered their removal, a trade group warned that numerous popular products — including Tylenol, Mucinex and Benadryl cold and flu remedies — might become unavailable as companies race to reformulate them.

From New York Times • Sep. 12, 2023

So is redness and swelling, which could explain why her red welts didn’t go away despite all the Benadryl she drank.

From "The Immortal Life of Henrietta Lacks" by Rebecca Skloot