diphenhydramine
Americannoun
Etymology
Origin of diphenhydramine
First recorded in 1945–50; diphen(yl) + hydr- 2 + amine
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
Anticholinergics also include diphenhydramine, the active ingredient in over-the-counter products like Benadryl.
From The Wall Street Journal ● Jan. 8, 2026
And while sedating antihistamines like diphenhydramine might help you sleep at night, they don't treat the cough itself.
From BBC ● Dec. 3, 2025
At 4:40 p.m., a nurse administered an injection that contained olanzapine, an antipsychotic used to treat schizophrenia and bipolar disorder, and diphenhydramine, an antihistamine for treating allergies and colds, according to the filing.
From Washington Post ● Apr. 26, 2023
For example, the active ingredient in Benadryl, diphenhydramine, is banned in Zambia in over-the counter products.
From New York Times ● Jan. 19, 2018
Medical solutions range from an antihistamine such as diphenhydramine as needed for the itching that can result from mild eczema to topical prescription steroid cream for more serious cases.
From Seattle Times ● Jan. 31, 2011
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