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Benadryl

American  
[ben-uh-dril] / ˈbɛn ə drɪl /
Pharmacology, Trademark.
  1. a brand of diphenhydramine.


Benadryl British  
/ ˈbɛnədrɪl /

noun

  1. an antihistamine drug used in sleeping tablets; diphenhydramine. Formula: C 17 H 21 NO

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

I was up almost every hour the first night and a few times the second, even with ear plugs from one of those Delta Air Lines in-flight amenity kits and Benadryl.

From The Wall Street Journal • Nov. 27, 2025

When the boy developed the rash, his family gave him the antihistamine Benadryl and soaked him in a bath at home, but it did not go away, according to Madisonville police.

From Seattle Times • Apr. 11, 2024

If you’re highly allergic to mosquitoes, he said, you may need a cream with Benadryl or similar antihistamine.

From Los Angeles Times • Feb. 14, 2024

Classic brand names like Benadryl, Claritin, Allegra, and Zyrtec are antihistamines, which can be used to treat, or lessen, that histamine reaction and thus the itch.

From Slate • Sep. 23, 2023

So is redness and swelling, which could explain why her red welts didn’t go away despite all the Benadryl she drank.

From "The Immortal Life of Henrietta Lacks" by Rebecca Skloot