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Benadryl

American  
[ben-uh-dril] / ˈbɛn ə drɪl /
Pharmacology, Trademark.
  1. a brand of diphenhydramine.


Benadryl British  
/ ˈbɛnədrɪl /

noun

  1. an antihistamine drug used in sleeping tablets; diphenhydramine. Formula: C 17 H 21 NO

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Anticholinergics also include diphenhydramine, the active ingredient in over-the-counter products like Benadryl.

From The Wall Street Journal • Jan. 8, 2026

One night, a nurse gave him the painkiller Norco, the antipsychotic Haldol, the sedative Ativan and the antihistamine Benadryl, according to the report from the Department of Public Health.

From Los Angeles Times • Mar. 20, 2025

When the boy developed the rash, his family gave him the antihistamine Benadryl and soaked him in a bath at home, but it did not go away, according to Madisonville police.

From Seattle Times • Apr. 11, 2024

At issue is phenylephrine, an almost-century-old ingredient in versions of Benadryl, Mucinex, Tylenol and other over-the-counter pills, syrups and liquids to clear up congested noses.

From Slate • Sep. 13, 2023

So is redness and swelling, which could explain why her red welts didn’t go away despite all the Benadryl she drank.

From "The Immortal Life of Henrietta Lacks" by Rebecca Skloot

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