1. either of two genes (BRCA1 or BRCA2 ) that, if inherited in a mutated form, may predispose some carriers to develop breast or ovarian cancer.

Origin of BRCA

1900–95; initialism from br(east) and ca(ncer)

Words Nearby BRCA

Other definitions for B.R.C.A. (2 of 2)


  1. Brotherhood of Railway Carmen of America. Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2023

How to use BRCA in a sentence

Scientific definitions for BRCA


[ bē′är′sē′ā ]

  1. One of two genes (designated BRCA1 and BRCA2) that help repair damage to DNA, but when inherited in a defective state increase the risk of breast and ovarian cancer.

The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.