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The Ice Bucket Challenge raised money for research into which disease?

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challenge

American  

[chal-inj] / ˈtʃæl ɪndʒ /

noun

• challenges
  plural

1. a call or summons to engage in any contest, as of skill, strength, etc.

2. something that by its nature or character serves as a call to battle, contest, special effort, etc..

   Space exploration offers a challenge to humankind.

3. a call to fight, as a battle, a duel, etc.

4. a demand to explain, justify, etc..

   a challenge to the treasurer to itemize expenditures.

5. difficulty in a job or undertaking that is stimulating to one engaged in it.

6. Military. the demand of a sentry for identification or a countersign.

7. Law. a formal objection to the qualifications of a particular juror, to that juror serving, or to the legality of an entire jury.

8. the assertion that a vote is invalid or that a voter is not legally qualified.

9. Biology. the process of inducing or assessing physiological or immunological activity by exposing an organism to a specific substance.

10. Hunting. the crying of a hound on finding a scent.

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verb (used with object)

• challenges,
  present (3rd person singular)
• challenged,
  past participle,  past
• challenging
  present participle

1. to summon to a contest of skill, strength, etc.

   Synonyms:

   invite, bid, dare

2. to take exception to; call in question.

   to challenge the wisdom of a procedure.

   Synonyms:

   doubt, impute, question

3. to demand as something due or rightful.

4. Military. to halt and demand identification or countersign from.

5. Law. to take formal exception to (a juror or jury).

6. to have a claim to; invite; arouse; stimulate.

   a matter which challenges attention.

7. to assert that (a vote) is invalid.

8. to assert that (a voter) is not qualified to vote.

9. to expose an organism to a specific substance in order to assess its physiological or immunological activity.

10. Archaic. to lay claim to.

verb (used without object)

• challenges,
  present (3rd person singular)
• challenged,
  past participle,  past
• challenging
  present participle

1. to make or issue a challenge.

2. Hunting. (of hounds) to cry or give tongue on picking up the scent.

adjective

1. donated or given by a private, corporate, or government benefactor on condition that the recipient raise an additional specified amount from the public.

   a challenge grant.

challenge British  

/ ˈtʃælɪndʒ /

verb

1. to invite or summon (someone to do something, esp to take part in a contest)

2. (also intr) to call (something) into question; dispute

3. to make demands on; stimulate

   the job challenges his ingenuity

4. to order (a person) to halt and be identified or to give a password

5. law to make formal objection to (a juror or jury)

6. to lay claim to (attention, etc)

7. (intr) hunting (of a hound) to cry out on first encountering the scent of a quarry

8. to inject (an experimental animal immunized with a test substance) with disease microorganisms to test for immunity to the disease

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noun

1. a call to engage in a fight, argument, or contest

2. a questioning of a statement or fact; a demand for justification or explanation

3. a demanding or stimulating situation, career, object, etc

4. a demand by a sentry, watchman, etc, for identification or a password

5. an assertion that a person is not entitled to vote or that a vote is invalid

6. law a formal objection to a person selected to serve on a jury ( challenge to the polls ) or to the whole body of jurors ( challenge to the array )

Other Word Forms

Derived Forms

• challenger
  noun
• prechallenge
  verb (used with object)
• rechallenge
  verb (used with object)
• challengeable
  adjective
• unchallengeable
  adjective
• unchallengeably
  adverb

Inflected Forms

Nouns

• challenges
  plural

Participles

• challenging
  present
• challenged
  past

Conjugated Forms

Present

• challenge
  simple
• challenges
  simple
• have challenged
  perfect
• has challenged
  perfect
• am challenging
  progressive
• are challenging
  progressive
• is challenging
  progressive
• have been challenging
  perfect progressive
• has been challenging
  perfect progressive

Past

• challenged
  simple
• had challenged
  perfect
• was challenging
  progressive
• were challenging
  progressive
• had been challenging
  perfect progressive

Future

• will challenge
  simple
• will have challenged
  perfect
• will be challenging
  progressive
• will have been challenging
  perfect progressive

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Etymology

Origin of challenge

First recorded in 1175–1225; Middle English chalenge, from Old French, variant of chalonge, from Latin calumnia “false statement”; see calumny

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Explanation

A challenge is something that puts you to the test — like running your first marathon or reading War and Peace. Challenge, as a verb, is derived from a Latin word meaning "to accuse falsely," and it is still used much as it was in the 13th century, in the sense of questioning whether something is true or right. Students sometimes challenge a weeknight curfew, and lawyers might challenge the evidence submitted by the other side in a lawsuit. Challenge is also used as a noun for a competition in which people challenge one another to prove that they’re the best at something.

Example Sentences

See Examples For:

challenge challenges challenged challenging

Alex Lane, Director of Operations at WWT, said rising costs and the challenge around income means charities like the WWT are facing "increasing pressure".

From BBC ● Oct. 17, 2026

Jeff Bezos’ Blue Origin is expanding rocket production in Florida as it works to challenge SpaceX’s launch business.

From Barron's ● Oct. 17, 2026

“It was a challenge getting CG to be accepted by directors and producers,” Cancado said.

From Los Angeles Times ● Oct. 17, 2026

By intentionally scripting ways to tighten these familial bonds from an early age—and recognizing the dynamics that can challenge them.

From The Wall Street Journal ● Oct. 17, 2026

She tilts her head, a silent challenge to what I know.

From "Red Flags and Butterflies" by Sheryl Azzam

AI agents inserting themselves between businesses and customers pose challenges for e-commerce players caught in the middle.

From The Wall Street Journal ● Oct. 16, 2026

A fresh approach to the dot plot and the Fed’s broader communication tools is overdue, and the timing is good as the central bank grapples with new and evolving challenges.

From MarketWatch ● Oct. 16, 2026

In a wide-ranging interview before the event, Kim — who was appointed in February after holding an interim presidential role — said he leads USC at a time of promise and deep challenges:

From Los Angeles Times ● Oct. 16, 2026

But does her sudden departure highlight the challenges broadcasters face covering the women's game in an ever-changing media landscape?

From BBC ● Oct. 16, 2026

With PJ. away at Duke, the Warden continued to face challenges.

From "Mountains Beyond Mountains" by Tracy Kidder and Michael French

It’s being challenged in Washington court and has a hearing scheduled for February.

From The Wall Street Journal ● Oct. 16, 2026

The court heard that, when O'Brien was arrested, he "argued with officers" and "challenged" them.

From BBC ● Oct. 13, 2026

Xavier’s aunt, Elizabeth Amaya, said Tuesday that she challenged the finding of suicide because if not for the fight, she said, Xavier would not have fled the classroom.

From Los Angeles Times ● Oct. 13, 2026

"Defendants shall not enter into, renew, or expand any agreement authorizing the development, creation, dissemination, placement, or airing of the challenged advertisements," Rochon said in the court order.

From Barron's ● Oct. 12, 2026

“No, the French only need salt, pepper, and butter,” Pierre challenged.

From "The Marvellers" by Dhonielle Clayton

The White House press secretary job is a challenging one, even under the best of circumstances.

From BBC ● Oct. 16, 2026

They are also challenging to modify genetically and can be damaged during freezing and storage, complicating the production and distribution of cell therapies.

From Science Daily ● Oct. 16, 2026

Establishing responsibility is challenging because it requires authorities to share maps pinpointing fire hotspots, with overlapping land claims further complicating matters.

From Barron's ● Oct. 16, 2026

The robots’ pincer-like hands make it challenging to grasp slippery and heavy ceramics.

From MarketWatch ● Oct. 16, 2026

In the town someone had stuck up a poster challenging people to solve a mathematical problem.

From "The Invention of Science" by David Wootton

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Related Words

• ask for
• assert
• call for
• claim
• confront
• defy
• demand
• denounce
• impose
• require
• test
• try

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