colchicine

American  

[kol-chuh-seen, -sin, kol-kuh-] / ˈkɒl tʃəˌsin, -sɪn, ˈkɒl kə- /

noun

Pharmacology.

1. a pale yellow, crystalline alkaloid, C 22 H 25 NO 6 , the active principle of colchicum.

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colchicine British  

/ ˈkɒltʃɪˌsiːn, ˈkɒlkɪ-, -sɪn /

noun

1. a pale-yellow crystalline alkaloid extracted from seeds or corms of the autumn crocus. It is used in the treatment of gout and to create polyploid plants by inhibiting chromosome separation during meiosis. Formula: C 22 H 25 NO 6

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Etymology

Origin of colchicine

First recorded in 1850–55; colchic(um) + -ine ²

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Example Sentences

See Examples For:

colchicine

High-throughput functional assays were validated using two classic atherosclerosis drugs, rosuvastatin and sirolimus, and were used to evaluate two drug candidates, curcumin and colchicine, and a potential gene therapy candidate, microRNA-146a-loaded liposomes, for treating atherosclerosis.

From Science Daily ● Jan. 13, 2024

After Ms. Bowman’s death, investigators collected information about Dr. Bowman’s internet searches, including research they said he had done earlier in August into the drug colchicine, which is used to treat gout.

From New York Times ● Oct. 25, 2023

The medical examiner’s office halted the order for cremation, citing suspicious circumstances, according to a criminal complaint, and an autopsy showed Betty Bowman died from toxic effects of colchicine, a medicine used to treat gout.

From Seattle Times ● Oct. 24, 2023

Likewise, the WHO recently recommended against using the gout drug colchicine or fluvoxamine for non-severe COVID-191.

From Scientific American ● Jul. 20, 2022

Taken internally, colchicum or colchicine markedly increases the amount of bile poured into the alimentary canal, being amongst the most powerful of known cholagogues.

From Encyclopaedia Britannica, 11th Edition, Volume 6, Slice 6 "Cockaigne" to "Columbus, Christopher" by Various

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