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constant region

American  

noun

  1. Immunology. the part of the polypeptide sequence in a heavy or light chain of an antibody forming the C-terminal portion of the chain and is the same for all members of the class it specifies. Compare variable region.

constant region Scientific  

  1. The portion of the amino acid sequence of an antibody's heavy or light chains that determines the class of the antibody and does not vary within a given class. The constant region terminates in a free carboxyl group (COOH). Unlike the variable region, the constant region does not interact with antigens.

  2. Compare variable region

Example Sentences

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In contrast, the constant region domain has less variation.

From Textbooks • Jun. 19, 2013

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023

Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.