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Synonyms

degenerative

American  
[dih-jen-er-uh-tiv, -uh-rey-tiv] / dɪˈdʒɛn ər ə tɪv, -əˌreɪ tɪv /

adjective

  1. tending to degenerate.

  2. characterized by degeneration.


degenerative British  
/ dɪˈdʒɛnəˌreɪtɪv /

adjective

  1. (of a disease or condition) getting steadily worse

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

  • nondegenerative adjective
  • undegenerative adjective

Etymology

Origin of degenerative

First recorded in 1840–50; degenerate + -ive

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

CTE is a degenerative brain disease that has been found in people exposed to repetitive head trauma; it can be diagnosed only after death.

From Los Angeles Times • Apr. 7, 2026

Petrou was diagnosed with retinitis pigmentosa, a degenerative disorder that leads to vision loss, at age 18.

From The Wall Street Journal • Mar. 12, 2026

The degenerative brain disease is linked to repeated blows to the head and causes an increased risk of mental illness.

From BBC • Feb. 10, 2026

Li, who suffers from a genetic degenerative condition that progressively weakens muscles, relies on a ventilator permanently connected to his windpipe to breathe, but grows celery with the help of his 62-year-old mother.

From Barron's • Jan. 29, 2026

Katie leaned forward, and I whispered the many problems I’d been suffering, which had led to the diagnosis of chronic, degenerative, relapsing-remitting inflammobetigoitis.

From "Liar, Liar" by Gary Paulsen