verb (used with object), de·plet·ed, de·plet·ing.

to decrease seriously or exhaust the abundance or supply of: The fire had depleted the game in the forest. Extravagant spending soon depleted his funds.

Origin of deplete

1800–10; < Latin dēplētus empty (past participle of dēplēre to empty out), equivalent to dē- de- + plē(re) to fill + -tus past participle suffix
Related formsde·plet·a·ble, adjectivede·ple·tion, nounde·ple·tive, de·ple·to·ry [dih-plee-tuh-ree] /dɪˈpli tə ri/, adjectivenon·de·plet·a·ble, adjectivenon·de·ple·tion, nounnon·de·ple·tive, adjectivenon·de·ple·to·ry, adjectivepre·de·plete, verb (used with object), pre·de·plet·ed, pre·de·plet·ing.pre·de·ple·tion, nounun·de·plet·ed, adjective

Synonyms for deplete Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

Related Words for depletion

deficiency, reduction

Examples from the Web for depletion

Contemporary Examples of depletion

Historical Examples of depletion

British Dictionary definitions for depletion


verb (tr)

to use up (supplies, money, energy, etc); reduce or exhaust
to empty entirely or partially
med to empty or reduce the fluid contents of (an organ or vessel)
Derived Formsdepletable, adjectivedepletion, noundepletive or depletory, adjective

Word Origin for deplete

C19: from Latin dēplēre to empty out, from de- + plēre to fill
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Word Origin and History for depletion

1650s, from Late Latin depletionem (nominative depletio) "blood-letting," noun of action from past participle stem of Latin deplere "to empty," literally "to un-fill," from de- "off, away" (see de-) + plere "to fill" (see pleio-).



1807, back-formation from depletion. Related: Depleted; depleting.

Online Etymology Dictionary, © 2010 Douglas Harper

depletion in Medicine




The act or process of depleting.
The state of being depleted; exhaustion.
Removal of or reduction in a body substance, such as blood, a fluid, or a nutrient.




To use up something, such as a nutrient.
To empty something out, as the body of electrolytes.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.