Dictionary.com
Thesaurus.com

dysregulate

American  
[dis-reg-yuh-layt] / dɪsˈrɛg jəˌleɪt /

verb (used with object)

  • dysregulates,
    present (3rd person singular)
  • dysregulated,
    past,  past participle
  • dysregulating
    present participle
  1. to disrupt a physical or psychological system's ability to adapt or respond appropriately to stimuli.


Other Word Forms

Derived Forms

Inflected Forms

Participles

Conjugated Forms

Present

Past

Future

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Those changes, Monje said, “can really powerfully dysregulate the interactions between multiple cell types, and it’s very clear that the crux of what goes wrong after cancer therapy is this same neuro-inflammation.”

From Washington Post Mar. 27, 2022

As the brain ages, immune activity can become dysregulated, potentially damaging nerve cells and disrupting communication between synapses.

From Science Daily Sep. 4, 2026

He said after the long summer holiday, some children returned "dysregulated" and struggling to adapt to routine.

From BBC Jul. 19, 2025

And when our bodies and brains become dysregulated, that’s when coping behaviors such as impulse or mindless shopping kick in to provide a boost of dopamine.

From Salon Dec. 6, 2024

When Polycomb proteins are integrated back into the cell, a subset of the genes are resistant to the proteins and remain dysregulated through cell division, allowing the cancer to continue its progression.

From Science Daily Apr. 24, 2024

It makes sense to feel dysregulated when faced with personal and global tragedy.

From Seattle Times Dec. 5, 2023

“We are dysregulating ecosystems and creating more opportunities for contact,” said Foley, the UC Davis veterinarian.

From Los Angeles Times Aug. 16, 2026

Additional experiments showed that several bile amidate compounds may promote gut inflammation by dysregulating T cell function.

From Science Daily Dec. 5, 2023

Prada, who has since moved to Lurie Children’s Hospital of Chicago, and his colleagues began incrementally changing Jack’s dose until they found one that maintained the drug’s benefits without dysregulating sleep.

From New York Times Jul. 6, 2022

The immune system: During a stressful event or period of time, stress hormones such as cortisol travel to the immune system and have various dysregulating effects.

From Washington Post Apr. 26, 2022

Vocabulary.com logo
by dictionary.com

Dictionary.com's Learning Companion

Go beyond just looking up words.
Remember them forever with VocabTrainer.

Start training