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dysregulate

American  
[dis-reg-yuh-layt] / dɪsˈrɛg jəˌleɪt /

verb (used with object)

  • dysregulates,
    present (3rd person singular)
  • dysregulated,
    past,  past participle
  • dysregulating
    present participle
  1. to disrupt a physical or psychological system's ability to adapt or respond appropriately to stimuli.


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Present

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Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Those changes, Monje said, “can really powerfully dysregulate the interactions between multiple cell types, and it’s very clear that the crux of what goes wrong after cancer therapy is this same neuro-inflammation.”

From Washington Post Mar. 27, 2022

He said after the long summer holiday, some children returned "dysregulated" and struggling to adapt to routine.

From BBC Jul. 19, 2025

"When Henry's dysregulated... he will lash out and he's not in control," she said.

From BBC Jun. 17, 2025

"Without this protein, the signals from the cells' environment turn from whispers into screams and the cells become stressed out and dysregulated."

From Science Daily Jun. 5, 2024

"These brain injury markers are associated with dysregulated systemic innate and adaptive immune responses in the acute phase of the disease, and suggest that these may represent targets for therapy," the authors concluded.

From Salon Dec. 27, 2023

It makes sense to feel dysregulated when faced with personal and global tragedy.

From Seattle Times Dec. 5, 2023

Additional experiments showed that several bile amidate compounds may promote gut inflammation by dysregulating T cell function.

From Science Daily Dec. 5, 2023

Prada, who has since moved to Lurie Children’s Hospital of Chicago, and his colleagues began incrementally changing Jack’s dose until they found one that maintained the drug’s benefits without dysregulating sleep.

From New York Times Jul. 6, 2022

The immune system: During a stressful event or period of time, stress hormones such as cortisol travel to the immune system and have various dysregulating effects.

From Washington Post Apr. 26, 2022

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