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dysregulate

American  
[dis-reg-yuh-layt] / dɪsˈrɛg jəˌleɪt /

verb (used with object)

  • dysregulates,
    present (3rd person singular)
  • dysregulated,
    past,  past participle
  • dysregulating
    present participle
  1. to disrupt a physical or psychological system's ability to adapt or respond appropriately to stimuli.


Other Word Forms

Derived Forms

Inflected Forms

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Conjugated Forms

Present

Past

Future


Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Those changes, Monje said, “can really powerfully dysregulate the interactions between multiple cell types, and it’s very clear that the crux of what goes wrong after cancer therapy is this same neuro-inflammation.”

From Washington Post ● Mar. 27, 2022

"When Nav1.7 becomes dysregulated, it contributes to both joint degeneration and pain," Liu says.

From Science Daily ● Oct. 8, 2026

He said after the long summer holiday, some children returned "dysregulated" and struggling to adapt to routine.

From BBC ● Jul. 19, 2025

"When Henry's dysregulated... he will lash out and he's not in control," she said.

From BBC ● Jun. 17, 2025

One might be dysregulated and operating in a constant flight-or-fight or freeze mode.

From Salon ● Feb. 1, 2025

They also discovered that all three infections induced a general inflammatory response in the placenta which dysregulated placental functions.

From Science Daily ● May 3, 2024

“We are dysregulating ecosystems and creating more opportunities for contact,” said Foley, the UC Davis veterinarian.

From Los Angeles Times ● Aug. 16, 2026

Additional experiments showed that several bile amidate compounds may promote gut inflammation by dysregulating T cell function.

From Science Daily ● Dec. 5, 2023

Prada, who has since moved to Lurie Children’s Hospital of Chicago, and his colleagues began incrementally changing Jack’s dose until they found one that maintained the drug’s benefits without dysregulating sleep.

From New York Times ● Jul. 6, 2022

The immune system: During a stressful event or period of time, stress hormones such as cortisol travel to the immune system and have various dysregulating effects.

From Washington Post ● Apr. 26, 2022

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