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fentanyl

American  
[fen-tuh-nil] / ˈfɛn tə nɪl /

noun

Pharmacology.
  1. a synthetic, short-acting narcotic analgesic and sedative, C 22 H 28 N 2 O, used pharmacologically in anesthesia and neuroleptanalgesia, and also as an illicit drug: Drug dealers are lacing heroin with fentanyl.

    Medics quickly administered fentanyl to the injured soldiers.

    Drug dealers are lacing heroin with fentanyl.


fentanyl British  
/ ˈfɛntəˌnaɪl /

noun

  1. a narcotic drug used in medicine to relieve pain

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of fentanyl

First recorded in 1960–65; contraction and respelling of the chemical name N-(1-phenethyl-4-piperidyl)propionanilide

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

On average, these patients received 8 μg more fentanyl during surgery, which researchers described as a modest increase.

From Science Daily May 20, 2026

The White House document claimed they had discussed Chinese investment in U.S. industries, purchases of U.S. oil and agricultural products, and ending the flow of fentanyl precursors into the U.S.

From Slate May 16, 2026

In a readout, the White House highlighted economic cooperation and building on recent progress to curb fentanyl flow.

From Barron's May 14, 2026

President Trump has linked tariffs on Beijing to its help fighting the fentanyl crisis.

From The Wall Street Journal Apr. 3, 2026

“The one case in which fentanyl can be absorbed through the skin is with a special doctor-prescribed fentanyl skin patch, and even then, it takes hours of exposure.”

From Los Angeles Times Feb. 24, 2026

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