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gastrointestinal

American

[gas-troh-in-tes-tuh-nl] / ˌgæs troʊ ɪnˈtɛs tə nl /

adjective

Anatomy.

of, relating to, or affecting the stomach and intestines.

gastrointestinal British

/ ˌɡæstrəʊɪnˈtɛstɪnəl /

adjective

of or relating to the stomach and intestinal tract

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of gastrointestinal

First recorded in 1825–35; gastro- + intestinal

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Between 40 and 70 percent of patients on these drugs report gastrointestinal adverse effects, like acid reflux, chronic diarrhea, and/or constipation.

From Slate • Mar. 22, 2026

Importantly, the compound works only within the gastrointestinal tract, which may help avoid unwanted side effects elsewhere in the body.

From Science Daily • Mar. 18, 2026

The scientists first evaluated the five compounds in laboratory experiments using human plasma samples and conditions that simulate gastrointestinal absorption.

From Science Daily • Mar. 8, 2026

The drug appeared to have a safe and well-tolerated profile, with some gastrointestinal side effects that were mild to moderate, and which diminished over time, the companies said.

From The Wall Street Journal • Feb. 24, 2026

Andy, Mike, Caroline, Lou, Stuart, and John suffered attacks of gastrointestinal distress that kept them racing to the latrine.

From "Into Thin Air" by Jon Krakauer

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023