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gene amplification

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noun Genetics.
an increase in the frequency of replication of a DNA segment.
such an increase induced by a polymerase chain reaction.
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Also called genetic amplification, DNA amplification .

Origin of gene amplification

First recorded in 1970–75

Words nearby gene amplification

Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2022

How to use gene amplification in a sentence

Scientific definitions for gene amplification

gene amplification

An increase in the number of copies of a gene in a cell, resulting in an elevation in the level of the RNA or protein encoded for by the gene and a corresponding amplification of the phenotype that the gene confers on the cell. Drug resistance in cancer cells is linked to amplification of the gene that prevents absorption of the chemotherapeutic agent by the cell.
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

Cultural definitions for gene amplification

gene amplification

A process in a cell by which a particular gene is replicated so that more copies are available to produce a protein for the cell's use. For example, the genes that code for proteins involved in ribosomes are amplified early in the process of cell development so that there are sufficient numbers of them to assemble the cell.

notes for gene amplification

PCR, polymerase chain reaction, can be considered a type of man-made gene amplification process.
The New Dictionary of Cultural Literacy, Third Edition Copyright © 2005 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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