glucocorticoid

American

[gloo-koh-kawr-ti-koid] / ˌglu koʊˈkɔr tɪˌkɔɪd /

noun

Biochemistry.

any of a class of steroid hormones that are synthesized by the adrenal cortex of vertebrates and have anti-inflammatory activity.

glucocorticoid British

/ ˌɡluːkəʊˈkɔːtɪˌkɔɪd /

noun

any of a class of corticosteroids that control carbohydrate, protein, and fat metabolism and have anti-inflammatory activity

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of glucocorticoid

1945–50; gluco- + cortic(o)- ( def. ) + -oid; cf. corticosteroid

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Surprisingly however, the effect was exactly the opposite: inhibiting the activity of FOXA1 further increased the activity of the glucocorticoid receptor -- and the development of drug resistance.

From Science Daily • Apr. 10, 2024

FOXA1 is known to have cancer-promoting properties, which is why the researchers assumed that inhibiting its activity would limit the development of glucocorticoid receptor-mediated drug-resistant prostate cancer.

From Science Daily • Apr. 10, 2024

This is because FOXA1 was found to be involved in the silencing of the glucocorticoid receptor gene, and this is what increased its activity when FOXA1 was inhibited.

From Science Daily • Apr. 10, 2024

However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer.

From Science Daily • Apr. 10, 2024

The glucocorticoid cortisone is actually naturally present in the body as cortisol, a stress hormone.

From Science Daily • Apr. 10, 2024

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023