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have occluded

  • present perfect
    of occlude.
    occlude
    verb (used with object)
    to close, shut, or stop up (a passage, opening, etc.).

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Rhodopsin and the S1P1 receptor have occluded binding pockets, presumably because they both bind hydrophobic ligands that may enter the receptor from the lipid bilayer.

From Nature Feb. 13, 2013

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