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herpes simplex

American  
[hur-peez sim-pleks] / ˈhɜr piz ˈsɪm plɛks /

noun

  1. either of two herpes diseases caused by a herpesvirus that infects humans and some other animals and produces small, transient blisters on the skin or mucous membranes, one type of virus herpes simplex virus type 1, or HSV-1 usually associated with oral herpes but also causing genital herpes and the other herpes simplex virus type 2, or HSV-2 usually causing genital herpes.

herpes simplex British  
/ ˈsɪmplɛks /

noun

  1. an acute viral disease characterized by formation of clusters of watery blisters, esp on the margins of the lips and nostrils or on the genitals. It can be sexually transmitted and may recur fitfully

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of herpes simplex

First recorded in 1905–10; from New Latin: literally, “simple herpes”

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

In Fayetteville, North Carolina, in 2020, as in other military towns across the U.S., rates of sexually transmitted infections like syphilis, herpes simplex and HIV are among the highest in the country.

From Salon • Jul. 20, 2025

Remarkably, people lacking functional UNC93B1 are prone to viral infections with a severe course, such as herpes simplex virus encephalitis and severe COVID-19, highlighting the essential role of UNC93B1 for a healthy immune system.

From Science Daily • Jan. 14, 2024

They didn’t have herpes simplex infection, a dangerous but treatable cause of encephalitis, or HIV, which can cause similar symptoms.

From Science Magazine • Nov. 21, 2023

Deaths caused by HSV-1 - herpes simplex 1 - are almost unheard of in healthy people.

From BBC • Jul. 26, 2023

The treatment, called Vyjuvek, uses an inactivated herpes simplex virus to deliver working copies of that gene.

From Seattle Times • Jul. 24, 2023

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023

Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.