syphilis

American  

[sif-uh-lis] / ˈsɪf ə lɪs /

noun

Pathology.

1. a chronic infectious disease, caused by a spirochete, Treponema pallidum, usually venereal in origin but often congenital, and affecting almost any organ or tissue in the body, especially the genitals, skin, mucous membranes, aorta, brain, liver, bones, and nerves.

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syphilis British  

/ ˈsɪfɪlɪs /

noun

1. a venereal disease caused by infection with the microorganism Treponema pallidum: characterized by an ulcerating chancre, usually on the genitals and progressing through the lymphatic system to nearly all tissues of the body, producing serious clinical manifestations

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syphilis Scientific  

/ sĭf′ə-lĭs /

1. A sexually transmitted disease caused by the spirochete Treponema pallidum that is characterized in its primary stage by genital sores. If untreated, skin ulcers develop in the next stage, called secondary syphilis. As the disease progresses to potentially fatal tertiary syphilis, neurologic involvement with weakness and skeletal or cardiovascular damage can occur.

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syphilis Cultural  

1. A sexually transmitted disease caused by a microorganism. In its initial stages (called primary syphilis), it is manifested by a skin ulcer called a chancre. If the disease is not treated by penicillin or other antibiotics, the infection becomes chronic. In so-called tertiary syphilis, virtually any tissue in the body can be damaged, including the cardiovascular and nervous systems. The disease, if left untreated, can cause blindness, mental illness, and death.

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Other Word Forms

• syphilitic
  adjective
• syphiloid
  adjective
• syphilitically
  adverb

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Etymology

Origin of syphilis

< New Latin, coined by Giovanni Fracastoro (1478–1553), Italian physician and poet, in his 1530 Latin poem Syphilis, sive morbus Gallicus (“Syphilis, or the French Disease”), an early account of syphilis

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Example Sentences

See Examples For:

syphilis

So far, no confirmed biological or genetic evidence of pre-Columbian venereal syphilis has been identified inside or outside the Americas.

From Science Daily ● Aug. 12, 2026

Treponematosis refers to a group of diseases that includes syphilis, yaws and endemic syphilis.

From Science Daily ● Aug. 12, 2026

Diagnoses of syphilis in gay and bisexual men dropped sharply – down 19% to their lowest level since 2016.

From BBC ● Jun. 2, 2026

He said congenital syphilis cases - "where infections pass directly to newborns, leading to potentially lifelong complications" - had nearly doubled from 2023 to 2024.

From BBC ● May 21, 2026

For a similar example in humans, we have only to consider the surprising evolution of syphilis.

From "Guns, Germs, and Steel: The Fates of Human Societies" by Jared M. Diamond

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Related Words

• AIDS
• acquired immune deficiency syndrome
• gonorrhea
• herpes
• the clap
• venereal disease

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