hormone replacement therapy

American  

[hawr-mohn ri-pleys-muhnt ther-uh-pee] / ˈhɔr moʊn rɪˌpleɪs mənt ˌθɛr ə pi /

noun

1. the administration of a particular sex hormone for therapeutic purposes, especially to treat a drop in production associated with aging or a disease. HRT

2. Also called gender-affirming hormone therapy.  Also called cross-sex hormone therapy.  the administration of androgens, estrogens, progestins, or androgen suppressants to a transgender person in order to align their secondary sexual characteristics with their gender identity. HRT

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hormone replacement therapy British  

noun

1.  HRT.  a form of oestrogen treatment used to control menopausal symptoms and in the prevention of osteoporosis

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hormone replacement therapy Scientific  

1. The therapeutic administration of estrogen and often progesterone to postmenopausal women in order to reduce symptoms and signs of estrogen deficiency, such as hot flashes and osteoporosis.

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Etymology

Origin of hormone replacement therapy

First recorded in 1965–70

Example Sentences

Years the Food and Drug Administration required “black box” warning labels on hormone replacement therapy for women.

From The Wall Street Journal • Nov. 12, 2025

I do an add-back hormone replacement therapy, which does lessen the side effects of the chemical menopause, but doesn’t allow my body to overcome Lupron fully.

From Slate • Jun. 14, 2025

With the new all-in-one tablet, there is no need for patients to remember to take hormone replacement therapy as a separate tablet.

From BBC • Mar. 12, 2025

Over its long history, hormone replacement therapy for women in menopause has been the Jekyll and Hyde of medications.

From Los Angeles Times • Jan. 21, 2025

Because of the heart attack, she had been taken off hormone replacement therapy and was constantly sweating.

From "Class Matters" by The New York Times