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The disorder causes constant, relentless hunger through hypothalamic dysfunction, where the brain fails to register fullness, often leading to life-threatening obesity.
From Barron's ● Apr. 6, 2026
In total, the team evaluated transcription from more than 50,000 single cells to identify hypothalamic cell populations that express FGF19 receptors.
From Science Daily ● Dec. 6, 2025
“Gut microbes communicate with the brain via the gut-brain axis, including tryptophan-kynurenine, immune, hypothalamic pituitary adrenal axis, and vagus nerve pathways.”
From Salon ● Dec. 7, 2023
An open question, Dulac adds, is whether these hypothalamic neurons can be activated by triggers other than pathogens, such as chronic inflammation.
From Scientific American ● Feb. 27, 2023
Non-neuronal cells may amplify these signals, which in turn activate the hypothalamic neurons that trigger the loss of appetite, fever and warmth-seeking.
From Washington Post ● Oct. 13, 2022
