proinsulin

American  

[proh-in-suh-lin, -ins-yuh-] / proʊˈɪn sə lɪn, -ˈɪns jə- /

noun

Biochemistry.

1. the prohormone of insulin, converted into insulin by enzymatic removal of part of the molecule.

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Etymology

Origin of proinsulin

First recorded in 1915–20; pro- ¹ + insulin

Example Sentences

See Examples For:

proinsulin

The investigators also identified additional partner proteins involved in folding and transporting proinsulin, as well as detecting and managing misfolded versions.

From Science Daily ● Jul. 28, 2026

When researchers genetically removed p58IPK from two different cell lines, misfolded proinsulin accumulated at higher levels.

From Science Daily ● Jul. 28, 2026

Their beta cells made smaller amounts of both proinsulin and insulin.

From Science Daily ● Jul. 28, 2026

The insulin and proinsulin, which would need to be extracted and purified for use, were expressed at a few grams per liter in the milk.

From Science Daily ● Mar. 13, 2024

"Our goal was to make proinsulin, purify it out to insulin, and go from there. But the cow basically processed it herself. She makes about three to one biologically active insulin to proinsulin," Wheeler said.

From Science Daily ● Mar. 13, 2024