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  • main line
    main line
    noun
    a principal line or route of a railroad, as contrasted with a branch or secondary one.
  • Main Line
    Main Line
    noun
    a fashionable residential district west of Philadelphia.
Synonyms

main line

1 American  

noun

  1. a principal line or route of a railroad, as contrasted with a branch or secondary one.

  2. a principal highway.

  3. Slang.

    1. a prominent and readily accessible vein of the body that may be used for a narcotic's injection.

    2. the act of mainlining.


Main Line 2 American  

noun

  1. a fashionable residential district west of Philadelphia.

  2. any fashionable district where socially prominent people live.


main line British  

noun

  1. railways

    1. the trunk route between two points, usually fed by branch lines

    2. ( as modifier )

      a main-line station

  2. a main road

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

verb

  1. slang (intr) to inject a drug into a vein

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

adjective

  1. having an important position, esp having responsibility for the main areas of activity

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

Etymology

Origin of main line

First recorded in 1835–45

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Rupireddy called Late Stage’s main line dozens of times, but he said no one answered.

From The Wall Street Journal Aug. 6, 2026

Warwickshire Police said its main line of inquiry was that a vehicle had hit the man and left the scene.

From BBC Apr. 5, 2026

Pike followed the main line — called the trunk line — which had hoses branching off in other directions.

From Los Angeles Times Mar. 11, 2026

The depletion of mangrove forests along the shoreline - the coast’s main line of defence against erosion - is to blame.

From BBC Aug. 13, 2024

This divide-and-conquer strategy is better than repeatedly allowing counterexamples to intrude into the main line of an argument while browbeating readers into looking away.

From "The Sense of Style" by Steven Pinker

Network Rail has warned that the Midland Main Line will remain closed to East Midlands Railway and Thameslink services until the end of the week.

From BBC Jun. 24, 2026

Lev, 49, started reaching out to other parents here, in Philadelphia’s wealthy Main Line suburbs, and he found hundreds of families who felt the same way.

From The Wall Street Journal Jun. 21, 2026

Cardinale grew up in Villanova, Penn., an affluent suburb on Philadelphia’s Main Line, and attended The Haverford School, an all-boys prep school.

From The Wall Street Journal Jan. 16, 2026

The operator said services along the Highland Main Line, between Inverness and Perth, was running.

From BBC Jan. 5, 2026

It’s on the prestigious Main Line, just twenty-five minutes outside Philadelphia, on a rolling campus surrounded by overgrown foliage.

From "The Other Wes Moore: One Name, Two Fates" by Wes Moore

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