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definitions

margin of safety

noun Pharmacology.
  1. therapeutic index.

Origin of margin of safety

1885–90, for an earlier sense
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018
margin of safety in Medicine

margin of safety

n.
  1. The amount between a therapeutic dose and a lethal dose of a drug.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.