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margin of safety

American  

noun

Pharmacology.
  1. therapeutic index.


Etymology

Origin of margin of safety

1885–90, for an earlier sense

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Implied volatility indicates the market’s expectations of how a security will move, up or down—but dealers often add what we call a fear or greed premium to provide themselves with a margin of safety.

From Barron's • May 13, 2026

The bond market is still pricing in over two interest-rate hikes by the European Central Bank this year, and the U.S. customer now carries a little less margin of safety than in February, he adds.

From The Wall Street Journal • Apr. 10, 2026

Processors may treat milk beyond minimum times or temperatures to provide an extra margin of safety, or to reduce bacteria that can cause milk to spoil, thus increasing the product's shelf life.

From Salon • May 20, 2024

This noncytotoxic nature underscores COE-PNH2's potential as a therapeutic agent with a wide margin of safety.

From Science Daily • Mar. 25, 2024

On a Model T Ford the reverse is your margin of safety.

From "Cannery Row" by John Steinbeck

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