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margin of safety

American  

noun

Pharmacology.
  1. therapeutic index.


Etymology

Origin of margin of safety

1885–90, for an earlier sense

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

The bond market is still pricing in over two interest-rate hikes by the European Central Bank this year, and the U.S. customer now carries a little less margin of safety than in February, he adds.

From The Wall Street Journal • Apr. 10, 2026

The stocks with the largest margin of safety include Amcor, Verizon, Kraft-Heinz, Best Buy, and Campbell’s.

From Barron's • Dec. 23, 2025

Processors may treat milk beyond minimum times or temperatures to provide an extra margin of safety, or to reduce bacteria that can cause milk to spoil, thus increasing the product's shelf life.

From Salon • May 20, 2024

This noncytotoxic nature underscores COE-PNH2's potential as a therapeutic agent with a wide margin of safety.

From Science Daily • Mar. 25, 2024

A chorus of engineers chanted that the thing could not be built, at least not with any margin of safety.

From "The Devil in the White City" by Erik Larson

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