noun Pathology.
  1. an abnormally large, immature, and dysfunctional red blood cell found in the blood of persons with pernicious anemia or certain other disorders.

Origin of megaloblast

First recorded in 1895–1900; megalo- + -blast
Related formsmeg·a·lo·blas·tic, adjective Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

Examples from the Web for megaloblastic

Historical Examples of megaloblastic

  • We can now say that the megaloblastic metamorphosis is not a purposeful process, and for the following reasons: 1.

  • Since the fresh formation of red blood corpuscles by means of the megaloblastic method is clearly much slower.

  • For this reason, the prognosis of megaloblastic anæmia, apart from the group of Bothriocephalus anæmia, is exceedingly bad.

  • In agreement with this, "blood crises" are not to be observed in the megaloblastic anæmias.

British Dictionary definitions for megaloblastic


  1. an abnormally large red blood cell precursor, present in certain types of anaemia
Derived Formsmegaloblastic (ˌmɛɡələʊˈblæstɪk), adjective
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

megaloblastic in Medicine


  1. An abnormally large nucleated red blood cell found especially in pernicious anemia or in certain vitamin deficiencies.
Related formsmeg′a•lo•blastic adj.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.