• synonyms


noun Pathology.
  1. an abnormally large, immature, and dysfunctional red blood cell found in the blood of persons with pernicious anemia or certain other disorders.
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Origin of megaloblast

First recorded in 1895–1900; megalo- + -blast
Related formsmeg·a·lo·blas·tic, adjective
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

Examples from the Web for megaloblast

Historical Examples

  • The megaloblast is probably a distinct cell, not merely a larger size of the normoblast.

    A Manual of Clinical Diagnosis

    James Campbell Todd

  • Any nucleated red cell, but especially the megaloblast, may exhibit polychromatophilia.

British Dictionary definitions for megaloblast


  1. an abnormally large red blood cell precursor, present in certain types of anaemia
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Derived Formsmegaloblastic (ˌmɛɡələʊˈblæstɪk), adjective
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

megaloblast in Medicine


  1. An abnormally large nucleated red blood cell found especially in pernicious anemia or in certain vitamin deficiencies.
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Related formsmeg′a•lo•blastic adj.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.