[ meth-oh-trek-seyt ]
/ ˌmɛθ oʊˈtrɛk seɪt /
a toxic folic acid analogue, C20H22N8O5, that inhibits cellular reproduction, used primarily in the treatment of psoriasis and certain cancers and as an immunosuppressive agent.
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Origin of methotrexate
1950–55; metho(xy)- + trexate, of unclear derivation
Words nearby methotrexate
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2020
British Dictionary definitions for methotrexate
/ (ˌmɛθəʊˈtrɛkseɪt, ˌmiːθəʊ-) /
an antimetabolite drug used in the treatment of certain cancers. Formula: C 20 H 22 N 8 O 5
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
Medical definitions for methotrexate
[ mĕth′ə-trĕk′sāt′ ]
A toxic antimetabolite that acts as a folic acid antagonist, used as an antineoplastic agent and in the treatment of rheumatoid arthritis and psoriasis.amethopterin
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
Scientific definitions for methotrexate
[ mĕth′ə-trĕk′sāt ]
A toxic drug that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases, such as rheumatoid arthritis. Chemical formula: C20H22N8O5.
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.