Dictionary.com

methotrexate

[ meth-oh-trek-seyt ]
/ ˌmɛθ oʊˈtrɛk seɪt /
Save This Word!

noun Pharmacology.
a toxic folic acid analogue, C20H22N8O5, that inhibits cellular reproduction, used primarily in the treatment of psoriasis and certain cancers and as an immunosuppressive agent.
QUIZ
WILL YOU SAIL OR STUMBLE ON THESE GRAMMAR QUESTIONS?
Smoothly step over to these common grammar mistakes that trip many people up. Good luck!
Question 1 of 7
Fill in the blank: I can’t figure out _____ gave me this gift.

Origin of methotrexate

1950–55; metho(xy)- + trexate, of unclear derivation
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2023

How to use methotrexate in a sentence

British Dictionary definitions for methotrexate

methotrexate
/ (ˌmɛθəʊˈtrɛkseɪt, ˌmiːθəʊ-) /

noun
an antimetabolite drug used in the treatment of certain cancers. Formula: C 20 H 22 N 8 O 5
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Scientific definitions for methotrexate

methotrexate
[ mĕth′ə-trĕksāt ]

A toxic drug that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases, such as rheumatoid arthritis. Chemical formula: C20H22N8O5.
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
FEEDBACK