methotrexate

American  

[meth-oh-trek-sayt] / ˌmɛθ oʊˈtrɛk seɪt /

noun

Pharmacology.

1. a toxic folic acid analogue, C 2 0 H 2 2 N 8 O 5 , that inhibits cellular reproduction, used primarily in the treatment of psoriasis and certain cancers and as an immunosuppressive agent.

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methotrexate British  

/ ˌmɛθəʊˈtrɛkseɪt, ˌmiːθəʊ- /

noun

1. an antimetabolite drug used in the treatment of certain cancers. Formula: C 20 H 22 N 8 O 5

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methotrexate Scientific  

/ mĕth′ə-trĕk′sāt /

1. A toxic drug that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases, such as rheumatoid arthritis. Chemical formula: C ₂₀ H ₂₂ N ₈ O ₅ .

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Etymology

Origin of methotrexate

1950–55; metho(xy)- + trexate, of unclear derivation

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Example Sentences

See Examples For:

methotrexate

Doctors only gave Thurman a methotrexate injection, a medication treatment, when her OB-GYN went to the hospital and spoke to the staff in person on her fourth visit to the emergency room.

From Salon ● May 26, 2026

Professor Cicuttini said in patients with hand OA and inflammation, the effects of methotrexate were present at about three months and by six months it was very clear if it worked.

From Science Daily ● Oct. 13, 2023

It so happened that this company was supplying the U.S. with half of its cisplatin, half of its methotrexate, 20 percent of its carboplatin.

From Slate ● Jul. 9, 2023

Isabella McDonald, then a junior at Utah Valley University, was diagnosed in April with a rare, often fatal bone cancer, whose sole treatment for young adults includes the drug methotrexate.

From Scientific American ● Jun. 21, 2023

The oncologist will probably come in to ask you some questions before we start the methotrexate.

From "Drums, Girls, and Dangerous Pie" by Jordan Sonnenblick

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