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  • mono
  • mono-
    mono-
    a combining form meaning “alone,” “single,” “one” (monogamy ); specialized in some scientific terms to denote a monomolecular thickness (monolayer ) and adapted in chemistry to apply to compounds containing one atom of a particular element (monohydrate ).
  • mono–
    mono–
    A prefix that means “one, only, single,” as in monochromatic, having only one color. It is often found in chemical names where it means “containing just one” of the specified atom or group, as in carbon monoxide, which is carbon attached to a single oxygen atom.

mono

1 American  
[mon-oh] / ˈmɒn oʊ /

noun

Informal.
  • monos
    plural
  1. infectious mononucleosis.


mono 2 American  
[mon-oh] / ˈmɒn oʊ /

adjective

  1. monophonic.


mono- 3 American  
especially before a vowel, mon-
  1. a combining form meaning “alone,” “single,” “one” (monogamy ); specialized in some scientific terms to denote a monomolecular thickness (monolayer ) and adapted in chemistry to apply to compounds containing one atom of a particular element (monohydrate ).


mono 1 British  
/ ˈmɒnəʊ /

adjective

  1. short for monophonic

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

noun

  1. monophonic sound; monophony

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
mono- 2 British  

combining form

  1. one; single

    monochrome

    monorail

  2. indicating that a chemical compound contains a single specified atom or group

    monoxide

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

mono– Scientific  
  1. A prefix that means “one, only, single,” as in monochromatic, having only one color. It is often found in chemical names where it means “containing just one” of the specified atom or group, as in carbon monoxide, which is carbon attached to a single oxygen atom.


Usage

What does mono- mean? Mono- is a combining form used like a prefix meaning “alone, singular, one.” It is used in a great many technical and scientific terms, including in chemistry, where it refers to compounds containing one atom of a particular element. Mono- comes from the Greek mónos, meaning “alone."What are variants of mono-?When combined with words or word elements that begin with a vowel, mono- becomes mon-, as in monacid.

Other Word Forms

Noun Inflected Forms

Etymology

Origin of mono1

By shortening

Origin of mono2

By shortening

Origin of mono-3

From Greek, combining form of mónos “alone”

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Early in his career, most albums were sold in two versions, mono and a more-expensive stereo format—a practice he described as expensive and wasteful in his autobiography.

From The Wall Street Journal ● Jun. 22, 2026

Her father’s mono bloc chair hasn’t moved from the spot it was last in since he passed.

From Los Angeles Times ● Apr. 13, 2026

Eventually we learned I had an immune condition; I also had mono, which felt cosmically unfair considering I had not yet been kissed and suspected I’d contracted it from the skating rink water fountain.

From Salon ● Mar. 31, 2026

It so happened the Cal baseball writer had just come down with mono.

From Seattle Times ● Nov. 10, 2023

The TV’s mono speaker emitted a brief electronic bip sound as I dropped the gray dot and picked up the egg.

From "Ready Player One: A Novel" by Ernest Cline

In fact, these oils contain a low amount - 5-10% - of unhealthy saturated fats and are high in healthier mono- and polyunsaturated fats.

From BBC ● Oct. 1, 2025

Emulsifiers, including sodium stearoyl lactylate and mono- and diglycerides.

From Seattle Times ● May 2, 2024

But typically bread only uses mono- or diglyceride fatty acids as emulsifiers, which have not been linked to risk of disease.

From Salon ● Jun. 14, 2023

When only one atom of the first element is present, the prefix mono- is usually deleted from that part.

From Textbooks ● Feb. 14, 2019

Their shirts were mono- grammed and their fingernails manicured.

From "I Know Why the Caged Bird Sings" by Maya Angelou

Whether his actual first words were, as his mother likes to remember, monos mou, "all by myself," they have become the memory that gives her son his identity.

From Time Magazine Archive

The reason why the machine is called a monotype is that the letters are made one at a time, and monos is the Greek word for one.

From Makers of Many Things by Eva March Tappan

Monadelpha is from monos, one and adelphos, brother.

From The Mushroom, Edible and Otherwise Its Habitat and its Time of Growth by Miron Elisha Hard

The word monarch is from two Greek words, monos sole or only, and arkos, a chief; and is a general name for a single ruler, whether he is called king, emperor, or prince.

From The Government Class Book Designed for the Instruction of Youth in the Principles of Constitutional Government and the Rights and Duties of Citizens. by Andrew W. Young

The word monologue comes from the combination of two Greek words, monos, alone, and legein, to speak.

From Writing for Vaudeville by Brett Page

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