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mononuclear

American  
[mon-uh-noo-klee-er, -nyoo-, -kyuh-ler] / ˌmɒn əˈnu kli ər, -ˈnju-, -kjə lər /

adjective

  1. Cell Biology. Also mononucleate. having only one nucleus.

  2. Chemistry. (of hydrocarbons) monocyclic.


mononuclear British  
/ ˌmɒnəʊˈnjuːklɪə /

adjective

  1. (of a cell) having only one nucleus

  2. another word for monocyclic

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Pronunciation

See nuclear.

Etymology

Origin of mononuclear

First recorded in 1885–90; mono- + nuclear

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

The team sequenced more than 1.25 million peripheral blood mononuclear cells, which are immune cells circulating in the bloodstream, from nearly 1,000 healthy people.

From Science Daily Aug. 20, 2026

Because the young mononuclear phagocytes did not appear to cross into the brain, researchers believe they may influence brain health indirectly.

From Science Daily Oct. 23, 2025

"We did not see that decline in mice receiving young mononuclear phagocytes, and we believe this may be responsible for some of the memory improvements that we observed."

From Science Daily Oct. 23, 2025

The cells, known as mononuclear phagocytes, normally circulate through the body to clear harmful substances.

From Science Daily Oct. 23, 2025

A fundamental distinction from the large mononuclear cells lies in the fact that the protoplasm exhibits a more or less numerous neutrophil granulation.

From Histology of the Blood Normal and Pathological by W. Myers

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