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multifactorial

American  
[muhl-tee-fak-tawr-ee-uhl, -tohr-, muhl-tahy-] / ˌmʌl ti fækˈtɔr i əl, -ˈtoʊr-, ˌmʌl taɪ- /

adjective

  1. having or stemming from a number of different causes or influences.

    Some medical researchers regard cancer as a multifactorial disease.


multifactorial British  
/ ˌmʌltɪfækˈtɔːrɪəl /

adjective

  1. genetics of or designating inheritance that depends on more than one gene

  2. involving or including a number of elements or factors

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

Etymology

Origin of multifactorial

First recorded in 1915–20; multi- + factor + -ial

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

The review highlights aging as a multifactorial process, meaning it is driven by many interacting biological factors instead of a single cause.

From Science Daily May 22, 2026

Diplomatic resolutions are multifactorial, especially when the military has been deployed.

From Barron's Mar. 4, 2026

“This could be a multifactorial presentation that we're seeing,” Lyons said.

From Science Magazine Apr. 4, 2024

“That just highlights the fact that autoimmunity is multifactorial, there's not a single cause or only a single way to get there,” Chang said.

From Salon Feb. 2, 2024

Most of the common diseases, such as heart disease, are multifactorial or polygenic, which refers to a phenotypic characteristic that is determined by two or more genes, and also environmental factors such as diet.

From Textbooks Apr. 25, 2013

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