1. of or relating to a system.
  2. Physiology, Pathology.
    1. pertaining to or affecting the body as a whole.
    2. pertaining to or affecting a particular body system.
  3. (of a pesticide) absorbed and circulated by a plant or other organism so as to be lethal to pests that feed on it.

Origin of systemic

First recorded in 1795–1805; system + -ic
Related formssys·tem·i·cal·ly, adverbnon·sys·tem·ic, adjective
Can be confusedsystematic systemic Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

British Dictionary definitions for non-systemic


  1. another word for systematic (def. 1), systematic (def. 2)
  2. physiol (of a poison, disease, etc) affecting the entire body
  3. (of a pesticide, fungicide, etc) spreading through all the parts of a plant and making it toxic to pests or parasites without destroying it
  1. a systemic pesticide, fungicide, etc
Derived Formssystemically, adverb
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Word Origin and History for non-systemic



1803, irregularly formed from system, used in medicine and biology for differentiation of meaning from systematic. Related: Systemically.

Online Etymology Dictionary, © 2010 Douglas Harper

non-systemic in Medicine


  1. Of or relating to a system.
  2. Of, relating to, or affecting the entire body or an entire organism.
  3. Relating to or affecting a particular body system, especially the nervous system.
  4. Relating to systemic circulation.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.