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Synonyms

systemic

American  
[si-stem-ik] / sɪˈstɛm ɪk /

adjective

  1. of or relating to a system, especially when affecting the entirety of a thing.

    systemic flaws in the design and construction of the vehicles.

  2. relating to or noting a policy, practice, or set of beliefs that has been established as normative or customary throughout a political, social, or economic system: systemic racism.

    systemic inequality;

    systemic racism.

  3. Physiology, Pathology.

    1. relating to or affecting the body as a whole.

    2. relating to or affecting a particular body system.

  4. (of a pesticide) absorbed and circulated by a plant or other organism so as to be lethal to pests that feed on it.


systemic British  
/ sɪˈstɛmɪk, -ˈstiː- /

adjective

  1. another word for systematic systematic

  2. physiol (of a poison, disease, etc) affecting the entire body

  3. (of a pesticide, fungicide, etc) spreading through all the parts of a plant and making it toxic to pests or parasites without destroying it

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

noun

  1. a systemic pesticide, fungicide, etc

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

Etymology

Origin of systemic

First recorded in 1795–1805; system + -ic

Explanation

Something that's systemic affects all parts of something. If every dog at doggy daycare has fleas, it's a systemic problem. The adjective systemic is often used to describe diseases or disorders; a systemic illness affects your whole body or an entire system — like your digestive system. Any kind of system can experience systemic problems. For example, crime is a systemic problem in a community because it affects everyone from individuals to families, businesses, and tourism, just to name a few groups harmed by the problem.

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Vocabulary lists containing systemic

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

“It is time for new leadership and systemic change.”

From Los Angeles Times ● Oct. 2, 2026

In a report following the first phase of the inquiry, chair Sir Martin Moore-Bick condemned LFB's "serious shortcomings" and systemic failures in its response to the fire.

From BBC ● Oct. 2, 2026

Researchers intend to launch a large randomized clinical trial testing whether prevention guided by imaging can slow or reduce the systemic progression of atherosclerosis.

From Science Daily ● Oct. 1, 2026

She has acknowledged the influence of Dickens’s “outrage, inventiveness and empathy,” and her sprawling books—larger-than-life, tragedy prone and sometimes ponderously socially conscious—depict systemic cruelty and heroic resilience.

From The Wall Street Journal ● Sep. 28, 2026

What may have looked like separate events were all evidence of seismic and systemic social change.

From "1919 The Year That Changed America" by Martin W. Sandler

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