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nondisjunction

American  
[non-dis-juhngk-shuhn] / ˌnɒn dɪsˈdʒʌŋk ʃən /

noun

Biology.
  1. the failure of chromosomes to separate and segregate into daughter cells at division.


nondisjunction British  
/ ˌnɒndɪsˈdʒʌŋkʃən /

noun

  1. the failure of paired homologous chromosomes to move to opposite poles of the cell during meiosis

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of nondisjunction

First recorded in 1910–15; non- + disjunction

Vocabulary lists containing nondisjunction

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

The M checkpoint checks for proper separation of sister chromatids and if it fails, then cells may undergo nondisjunction of chromosomes.

From Textbooks Jun. 9, 2022

Down Syndrome is a genetic, developmental condition caused by nondisjunction of chromosome 21 during meiosis.

From Textbooks Jun. 9, 2022

Aneuploidy results when the gametes have too many or too few chromosomes due to nondisjunction during meiosis.

From Textbooks Jan. 1, 2015

The most common cause of trisomy 21 is chromosomal nondisjunction during meiosis.

From Textbooks Jun. 19, 2013

The risk of nondisjunction increases with the age of the parents.

From Textbooks Apr. 25, 2013

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