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nondisjunction

American  
[non-dis-juhngk-shuhn] / ˌnɒn dɪsˈdʒʌŋk ʃən /

noun

Biology.

  1. the failure of chromosomes to separate and segregate into daughter cells at division.

nondisjunction British  
/ ˌnɒndɪsˈdʒʌŋkʃən /

noun

  1. the failure of paired homologous chromosomes to move to opposite poles of the cell during meiosis

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of nondisjunction

First recorded in 1910–15; non- + disjunction

Vocabulary lists containing nondisjunction

Genetics - Middle School

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Genetics - High School

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Example Sentences

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They are caused by nondisjunction, which occurs when pairs of homologous chromosomes or sister chromatids fail to separate during meiosis.

From Textbooks • Jun. 9, 2022

The M checkpoint checks for proper separation of sister chromatids and if it fails, then cells may undergo nondisjunction of chromosomes.

From Textbooks • Jun. 9, 2022

If nondisjunction occurs during meiosis, gametes with an abnormal number of chromosomes may result, leading to a disorder of chromosome numbers.

From Textbooks • Jan. 1, 2018

In males, nondisjunction may cause Klinefelter’s syndrome, resulting from the inheritance of an extra X chromosome.

From Textbooks • Jan. 1, 2018

The risk of nondisjunction increases with the age of the parents.

From Textbooks • Apr. 25, 2013

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023

Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.